THE USE OF THE CHANNELFORMING OF POLYENE ANTIBIOTICS AT THE MUSCLE PERFORMANCE

Abstract

This study intended to compare the action of levorin A2 antibiotic on permeability properties bilayer lipid membranes and biological muscle membranes to ions and some organic molecules. The molecular organization of levorin A2 complexes responsible for the induced ion permeability in lipid and biological membranes remains obscure. Comparison of the results in lipid bilayers and muscle membranes can be used the polyene action to amplify the muscle performance. It’s showed that nonaromatic and aromatic heptaene polyene macrolide antibiotics induced in lipid bilayers and frog isolated skeletal muscle fibers cation conductance for K+, Na+, Ca++ ions, and neutral molecules in the following number series: H2O > urea > acetamide > glycerine > ribose > arabinose > glucose > saccharose. In the presence of levorin A2 can be the speed of motion in tissue of muscle fibers of energy-dependent substrates and escaping them of the derivated products of metabolism at intensive muscle performance.